CUSIP No. 02155H200
|
13G
|
Page 2 of 10 Pages
|
|||
1
|
NAME OF REPORTING PERSONS
Sphera Funds Management Ltd.
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Israel
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON WITH
|
5
|
SOLE VOTING POWER
---
|
|||
6
|
SHARED VOTING POWER
3,775,618 (*)
|
||||
7
|
SOLE DISPOSITIVE POWER
---
|
||||
8
|
SHARED DISPOSITIVE POWER
3,775,618 (*)
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,775,618 (*)
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)
☐
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.84% (*) (**)
|
||||
12
|
TYPE OF REPORTING PERSON (See instructions)
CO
|
CUSIP No. 02155H200
|
13G
|
Page 3 of 10 Pages
|
|||
1
|
NAME OF REPORTING PERSONS
Sphera Global Healthcare GP Ltd.
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Israel
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON WITH
|
5
|
SOLE VOTING POWER
---
|
|||
6
|
SHARED VOTING POWER
3,775,618 (*)
|
||||
7
|
SOLE DISPOSITIVE POWER
---
|
||||
8
|
SHARED DISPOSITIVE POWER
3,775,618 (*)
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,775,618 (*)
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)
☐
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.84% (*)
(**)
|
||||
12
|
TYPE OF REPORTING PERSON (See instructions)
CO
|
CUSIP No. 02155H200
|
13G
|
Page 4 of 10 Pages
|
|||
1
|
NAME OF REPORTING PERSONS
Sphera Global Healthcare Management LP
|
||||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See instructions)
(a) ☐
(b) ☒
|
||||
3
|
SEC USE ONLY
|
||||
4
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Israel
|
||||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON WITH
|
5
|
SOLE VOTING POWER
---
|
|||
6
|
SHARED VOTING POWER
3,775,618 (*)
|
||||
7
|
SOLE DISPOSITIVE POWER
---
|
||||
8
|
SHARED DISPOSITIVE POWER
3,775,618 (*)
|
||||
9
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,775,618 (*)
|
||||
10
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)
☐
|
||||
11
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.84% (*) (**)
|
||||
12
|
TYPE OF REPORTING PERSON (See instructions)
CO
|
Item 1. (a) |
Name of Issuer:
|
(b) |
Address of Issuer's Principal Executive Offices:
|
Item 2. (a) |
Name of Person Filing:
|
(b) |
Address of Principal Business Office:
|
(c) |
Citizenship:
|
(d) |
Title of Class of Securities:
|
(e) |
CUSIP Number:
|
Item 3. |
Not applicable.
|
Item 4. |
Ownership:
|
(a) |
Amount beneficially owned:
|
• |
2,117,080 shares of Common Stock (or options exercisable into shares of Common Stock), representing a total of 4.96% of the total shares of Common Stock outstanding, are held directly by Sphera Global Healthcare Master Fund, which has
delegated its investment management authority to Sphera Global Healthcare Management LP (the "Management Company").
|
• |
1,658,538 shares of Common Stock (or options exercisable into shares of Common Stock), representing a total of 3.88% of the total shares of Common Stock outstanding, are held directly by Sphera Biotech Master Fund, L.P., which has
delegated its investment management authority to the Management Company.
|
(b) |
Percent of class:
|
(c) |
Number of shares as to which such person has:
|
(i) |
Sole power to vote or to direct the vote:
|
(ii) |
Shared power to vote or to direct the vote:
|
(iii) |
Sole power to dispose or to direct the disposition of:
|
(iv) |
Shared power to dispose or to direct the disposition of:
|
Item 5. |
Ownership of Five Percent or Less of a Class:
|
Item 6. |
Ownership of More than Five Percent on Behalf of Another:
|
Item 7. |
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:
|
Item 8. |
Identification and Classification of Members of the Group:
|
Item 9. |
Notice of Dissolution of Group:
|
Item 10. |
Certification:
|
Sphera Funds Management Ltd.
/s/ Neomi Elpeleg
By: Neomi Elpeleg
Title: Chief Financial Officer
Sphera Global Healthcare GP Ltd.
/s/ Neomi Elpeleg
By: Neomi ElpelegTitle: Chief Financial Officer
Sphera Global Healthcare Management LP
/s/ Neomi Elpeleg
By: Neomi ElpelegTitle: Chief Financial Officer |
EXHIBIT NO. |
DESCRIPTION
|
Exhibit 1 |
Sphera Funds Management Ltd.
/s/ Neomi Elpeleg By: Neomi Elpeleg
Title: Chief Financial Officer
Sphera Global Healthcare GP Ltd.
/s/ Neomi Elpeleg By: Neomi Elpeleg
Title: Chief Financial Officer
Sphera Global Healthcare Management
LP
/s/ Neomi Elpeleg By: Neomi Elpeleg
Title: Chief Financial Officer |