Entity Central Index Key
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity File Number
Entity File Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Also includes the aggregate carrying amount, as of the balance sheet date, of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered and of liabilities not separately disclosed in the balance sheet. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Restricted cash
Restricted Cash Current
Total cash, cash equivalents, and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Short-term investments
Short Term Investments
Accounts receivable
Accounts Receivable Gross Current
Tax refund receivable
Income Taxes Receivable
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Right of use asset
Operating Lease Right Of Use Asset
Intangible assets, net
Intangible Assets Net Excluding Goodwill
Other assets
Other Assets Noncurrent
Total assets
Assets
Liabilities, Redeemable Convertible Preferred Stock and Stockholders’ Equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Notes payable
Notes Payable Current
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities
Total current liabilities
Liabilities Current
Deferred income taxes
Deferred Tax Liabilities Noncurrent
Contingent consideration
Business Combination Contingent Consideration Liability Noncurrent
Other long-term liabilities
Other Long Term Debt Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 16)
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Common stock, $0.0001 par value; 200,000,000 shares authorized; 15,312,381 and 9,078,735 shares issued; 15,312,167 and 9,078,238 shares outstanding at December 31, 2019 and 2018, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital
Accumulated deficit
Retained Earnings Accumulated Deficit
Accumulated other comprehensive loss, net
Accumulated Other Comprehensive Income Loss Net Of Tax
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Common stock, par or stated value per share
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
Revenue
Revenue From Contract With Customer Excluding Assessed Tax
Operating expenses
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Impairment charges
Asset Impairment Charges
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income (expense)
Nonoperating Income Expense [Abstract]
Changes in fair value of warrant liability, including loss on exchange
Debt Securities Unrealized Gain Loss
Changes in fair value of embedded derivative
Unrealized Gain Loss On Derivatives
Interest expense
Interest Expense
Interest income
Investment Income Interest
Other income, net
Other Nonoperating Income Expense
Total other income (expense)
Nonoperating Income Expense
Net loss before income tax benefit
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax benefit
Income Tax Expense Benefit
Net loss
Net Income Loss
Other comprehensive loss — foreign currency translation adjustment
Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax
Other comprehensive income — unrealized gains on investments
Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax Including Portion Attributable To Noncontrolling Interest
Net loss
Preferred stock accretion and other deemed dividends
Preferred Stock Dividends And Other Adjustments
Net loss attributable to common stockholders
Net Income Loss Available To Common Stockholders Basic
Weighted-average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Net loss per share attributable to common stockholders, basic and diluted
Earnings Per Share Basic And Diluted
Adjustments to additional paid in capital accretion of convertible preferred stock.
Temporary equity shares conversion of convertible preferred stock.
Temporary equity value conversion of convertible preferred stock.
Reclassification of shares from temporary equity to permanent equity.
Stock issued during period value redemption of convertible securities.
Stock issued during period share exchange of warrants.
Stock issued during period value exchange of warrants.
Stock issued during period share exercise of warrants.
Stock issued during period value exercise of warrants.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Other Comprehensive Income [Member]
Class of Stock
Statement Class Of Stock [Axis]
Class of Stock
Class Of Stock [Domain]
Series B redeemable convertible preferred stock.
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Public Offering [Member]
I P O [Member]
Statement [Line Items]
Statement [Line Items]
Beginning Balance
Beginning Balance (in shares)
Temporary Equity Shares Outstanding
Beginning Balance
Temporary Equity Carrying Amount Including Portion Attributable To Noncontrolling Interests
Beginning Balance (in shares)
Shares Outstanding
Stock based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Adjustments to additional paid in capital share based compensation requisite service period recognition shares.
Stock based compensation (in shares)
Adjustments To Additional Paid In Capital Share Based Compensation Requisite Service Period Recognition Shares
Vesting and accelerated vesting of restricted stock, net
Restricted Stock Value Shares Issued Net Of Tax Withholdings
Vesting and accelerated vesting of restricted stock, net (in shares)
Restricted Stock Shares Issued Net Of Shares For Tax Withholdings
Exercises of stock options
Stock Issued During Period Value Stock Options Exercised
Exercises of stock options (in shares)
Stock Issued During Period Shares Stock Options Exercised
Issuance of Series B redeemable convertible preferred stock and warrants, net of issuance costs and discounts
Temporary Equity Stock Issued During Period Value New Issues
Temporary Equity Stock Issued During Period Shares New Issues
Issuance of Series B redeemable convertible preferred stock and warrants, net of issuance costs and discounts (in shares)
Temporary Equity Stock Issued During Period Shares New Issues
Accretion of Series B redeemable convertible preferred stock
Adjustments To Additional Paid In Capital Accretion Of Convertible Preferred Stock
Accretion of Series B redeemable convertible preferred stock
Temporary Equity Accretion To Redemption Value
Conversion of Series B redeemable convertible preferred stock into common stock
Reclassifications Of Temporary To Permanent Equity
Conversion of Series B redeemable convertible preferred stock into common stock (in shares)
Temporary Equity Shares Conversion Of Convertible Preferred Stock
Conversion of Series B redeemable convertible preferred stock into common stock
Temporary Equity Value Conversion Of Convertible Preferred Stock
Conversion of Series B redeemable convertible preferred stock into common stock (in shares)
Reclassification Of Shares From Temporary Equity To Permanent Equity
Redemption of Series B redeemable convertible preferred stock for cash and release of embedded derivative
Stock Issued During Period Value Redemption Of Convertible Securities
Redemption of Series B redeemable convertible preferred stock for cash and release of embedded derivative (in shares)
Stock Issued During Period Shares Conversion Of Convertible Securities
Redemption of Series B redeemable convertible preferred stock for cash and release of embedded derivative
Stock Issued During Period Value Conversion Of Convertible Securities
Issuance of common stock for the exchange of warrants
Stock Issued During Period Value Exchange Of Warrants
Issuance of common stock for the exchange of warrants (in shares)
Stock Issued During Period Share Exchange Of Warrants
Issuance of common stock upon exercise of warrants
Stock Issued During Period Value Exercise Of Warrants
Issuance of common stock upon exercise of warrants (in shares)
Stock Issued During Period Share Exercise Of Warrants
Issuance of common stock and units, net of offerings cost
Stock Issued During Period Value New Issues
Issuance of common stock and units, net of offering costs (in shares)
Stock Issued During Period Shares New Issues
Issuance of common stock for acquired in-process research and development
Stock Issued During Period Value Acquisitions
Issuance of common stock for acquired in-process research and development (in shares)
Stock Issued During Period Shares Acquisitions
Foreign currency translation adjustments
Unrealized gain on short term investments
Ending Balance
Ending Balance (in shares)
Ending Balance
Ending Balance (in shares)
Debt discount accretion.
Increase decrease in lease obligations.
Proceeds from conditional economic incentive.
Proceeds from exercises of warrants and stock options.
Common stock issued for acquired in-process research and development.
Settlement of warrant liability for common stock.
Notes payable related to the exchange of warrants.
Statement Of Cash Flows [Abstract]
CASH FLOWS FROM OPERATING ACTIVITIES
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Non-cash consideration for acquired in-process research and development
Research And Development In Process
Stock-based compensation
Share Based Compensation
Depreciation
Depreciation
Amortization
Adjustment For Amortization
Unrealized (gain) loss on foreign currency exchange
Foreign Currency Transaction Gain Loss Unrealized
Debt discount accretion
Debt Discount Accretion
Gain from disposal of property and equipment
Gain Loss On Sale Of Property Plant Equipment
Changes in fair value of warrant liability
Fair Value Adjustment Of Warrants
Changes in fair value of embedded derivative
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable
Increase Decrease In Accounts Receivable
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses and other current liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Deferred revenue
Increase Decrease In Contract With Customer Liability
Deferred rent
Increase Decrease In Prepaid Rent
Lease obligation
Increase Decrease In Lease Obligations
Tax refund receivable
Increase Decrease In Income Taxes Receivable
Deferred tax benefit
Deferred Income Tax Expense Benefit
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
CASH FLOWS FROM INVESTING ACTIVITIES
Net Cash Provided By Used In Investing Activities [Abstract]
Cash paid for short-term investments
Payments To Acquire Available For Sale Securities Debt
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Proceeds from sale of property and equipment
Proceeds From Sale Of Property Plant And Equipment
Additions to intangible assets
Payments To Acquire Intangible Assets
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
CASH FLOWS FROM FINANCING ACTIVITIES
Net Cash Provided By Used In Financing Activities [Abstract]
Repayments of notes payable
Repayments Of Notes Payable
Redemption of preferred stock
Payments For Repurchase Of Preferred Stock And Preference Stock
Cash paid in conjunction with warrant exchange
Payments For Repurchase Of Warrants
Proceeds from conditional economic incentive
Proceeds From Conditional Economic Incentive
Proceeds from issuance of common stock, net of issuance costs
Proceeds From Issuance Of Common Stock
Proceeds from issuance of common units, net of issuance costs
Proceeds From Issuance Of Common Limited Partners Units
Proceeds from exercise of warrants and stock options
Proceeds From Exercises Of Warrants And Stock Options
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
EFFECT OF EXCHANGE RATES ON CASH, CASH EQUIVALENTS, AND RESTRICTED CASH
Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Net (decrease) increase in cash, cash equivalents, and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents, and restricted cash — beginning of year
Cash, cash equivalents, and restricted cash — end of year
SUPPLEMENTAL CASH FLOW INFORMATION
Supplemental Cash Flow Information [Abstract]
Cash paid for interest
Interest Paid Net
SUPPLEMENTAL NON-CASH FINANCING ACTIVITIES
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Conversion of Series B redeemable convertible preferred stock into common stock
Conversion Of Stock Amount Issued1
Common Stock issued for acquired in-process research and development
Common Stock Issued For Acquired In Process Research And Development
Settlement of warrant liability for common stock
Settlement Of Warrant Liability For Common Stock
Notes payable issued in conjunction with the exchange of warrants
Notes Payable Related To Exchange Of Warrants
Accretion of Series B redeemable convertible preferred stock
Preferred Stock Accretion Of Redemption Discount
Accounting Policies [Abstract]
Nature of Business and Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Business Combinations [Abstract]
Acquisitions
Business Combination Disclosure [Text Block]
Earnings Per Share [Abstract]
Net Loss Per Share
Earnings Per Share [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Goodwill And Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets
Goodwill And Intangible Assets Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Licenses
Collaborative Arrangement Disclosure [Text Block]
Notes payable and other liabilities.
Notes payable and other liabilities.
Notes Payable And Other Liabilities Disclosure [Abstract]
Notes Payable and Other Liabilities
Notes Payable And Other Liabilities
Equity [Abstract]
Preferred Stock
Preferred Stock [Text Block]
The entire disclosure of common stock.
Text Block [Abstract]
Common Stock
Common Stock [Text Block]
Warrants
Stockholders Equity Note Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Leases [Abstract]
Lease Obligations
Lessee Operating Leases [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurement
Fair Value Disclosures [Text Block]
Compensation And Retirement Disclosure [Abstract]
Employee Benefit Plans
Pension And Other Postretirement Benefits Disclosure [Text Block]
Principles of Consolidation
Consolidation Policy [Text Block]
Use of Estimates
Use Of Estimates
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Foreign Currency Translation
Foreign Currency Transactions And Translations Policy [Text Block]
Segment
Segment Reporting Policy Policy [Text Block]
Investments
Investment Policy [Text Block]
Intangible Assets
Goodwill And Intangible Assets Intangible Assets Policy
Impairment of Long-lived Assets and Goodwill
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Financial Instruments
Fair Value Of Financial Instruments Policy
Revenue
Revenue Recognition Policy [Text Block]
Research and Development
Research And Development Expense Policy
Clinical Trial Costs
Health Care Costs Policy Policy [Text Block]
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Accounts Receivable
Trade And Other Accounts Receivable Policy
Concentrations of Credit Risk
Concentration Risk Credit Risk
Property and Equipment, Net
Property Plant And Equipment Policy [Text Block]
Preferred Stock
Stockholders Equity Note Redeemable Preferred Stock Issue Policy
Disclosure of accounting policy for warrants.
Warrants
Warrants Policy [Text Block]
Stock-based Compensation
Share Based Compensation Option And Incentive Plans Policy
Income Taxes
Income Tax Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Contingent consideration.
Contingent Consideration
Contingent Consideration Policy [Text Block]
Recently Issued Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
The element represents about the property and equipment estimated useful lives.
Summary of Depreciation and Amortization Recorded using Straight-line Method over Estimated Useful Lives
Property And Equipment Estimated Useful Lives Table [Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Summary of Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of intangible assets.
Schedule of Intangible Assets
Schedule Of Intangible Assets Table [Text Block]
Schedule of Future Estimated Amortization Expense
Scheduleof Finite Lived Intangible Assets Future Amortization Expense Table [Text Block]
Schedule of Changes in Carrying Amounts of IPR&D Assets and Goodwill
Schedule Of Intangible Assets And Goodwill Table [Text Block]
Schedule of Accrued Expense and Other Current Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Summary of Current Portion of Outstanding Notes Payable
Other Current Liabilities Table [Text Block]
Summary of Long-term Portion of Outstanding Notes Payable as well as Other Long-Term Liabilities
Other Noncurrent Liabilities Table [Text Block]
Summary of Periodic Changes Fair Value of Embedded Redemption Derivative Financial Instrument
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Text Block]
Schedule of warrants outstanding and exercisable.
Valuation Approach and Technique
Valuation Technique [Axis]
Valuation Approach and Technique
Valuation Technique [Domain]
Monte Carlo simulation model.
Monte Carlo Simulation Model [Member]
Monte Carlo Simulation Model [Member]
Summary of Common Stock Warrants Outstanding
Schedule Of Warrants Outstanding And Exercisable Table [Text Block]
Key Assumptions Used in Calculating Marketability Discount [Table Text Block]
Summary of Key Assumptions Used in Calculating Marketability Discount
Key Assumptions Used In Calculating Marketability Discount Table [Text Block]
Schedule of income statement effect of changes in outstanding warrants.
Summary of Income Statement Effect of Changes in Outstanding Warrants
Schedule Of Income Statement Effect Of Changes In Outstanding Warrants Table [Text Block]
Summary of Warrant Activity
Schedule Of Stockholders Equity Note Warrants Or Rights [Text Block]
Summary of Periodic Changes in Fair Value of Warrant Liability
Schedule Of Derivative Liabilities At Fair Value Table [Text Block]
Summary of Assumptions Used to Estimate Fair Value
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Summary of Fair Value of Stock Options Issued to Employees
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Information Related to Stock Options Outstanding
Schedule Of Other Share Based Compensation Activity Table [Text Block]
Summary of Restricted Stock Activity
Nonvested Restricted Stock Shares Activity Table [Text Block]
Schedule of Stock-based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Components of Net Loss Before Income Tax Benefit
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Components of Income Tax Benefits
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Reconciliation Between Effect of Applying Federal Statutory Rate and Effective Income Tax Rate Used to Calculate Income Tax Benefit
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Components of Deferred Tax Assets and Liabilities
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Schedule of supplemental balance sheet information related to Operating leases.
Summary of Supplemental other Information Related to Operating Leases Balance Sheet
Schedule Of Supplemental Balance Sheet Information Related To Operating Leases Table [Text Block]
Summary of Maturities of Lease Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Fair Value Assets and Liabilities Measured on Recurring Basis
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block]
Schedule of Short Term Investments
Schedule Of Available For Sale Securities Reconciliation Table [Text Block]
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
IPR&D [Member]
In Process Research And Development [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Concentration Risk Type
Concentration Risk By Type [Axis]
Concentration Risk Type
Concentration Risk Type [Domain]
Revenue from Rights Concentration Risk [Member]
Revenue From Rights Concentration Risk [Member]
Concentration Risk Benchmark
Concentration Risk By Benchmark [Axis]
Concentration Risk Benchmark
Concentration Risk Benchmark [Domain]
Research Grants and Contracts [Member]
Revenue From Contract With Customer [Member]
Accounts Receivable [Member]
Accounts Receivable [Member]
Adjustments for New Accounting Pronouncements
Adjustments For New Accounting Pronouncements [Axis]
Type of Adoption
Type Of Adoption [Member]
ASU 2016-02 [Member]
Accounting Standards Update201602 [Member]
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Number of operating segments
Number Of Operating Segments
Intangible assets amortization period
Finite Lived Intangible Assets Remaining Amortization Period1
Impairments
Impairment Of Intangible Assets Indefinitelived Excluding Goodwill
Goodwill impairment charges
Goodwill Impairment Loss
Goodwill
Goodwill
Fair value transfers, Level 1 to Level 2 assets
Fair Value Assets Level1 To Level2 Transfers Amount
Fair value transfers, Level 2 to Level 1 assets
Fair Value Assets Level2 To Level1 Transfers Amount
Fair value transfers, Level 1 to Level 2 liabilities
Fair Value Liabilities Level1 To Level2 Transfers Amount
Fair value transfers, Level 2 to Level 1 liabilities
Fair Value Liabilities Level2 To Level1 Transfers Amount
Release in restricted cash.
Restricted cash released
Release In Restricted Cash
Percentage of concentration of credit risk
Concentration Risk Percentage1
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment, Type
Property Plant And Equipment By Type [Axis]
Property, Plant and Equipment, Type
Property Plant And Equipment Type [Domain]
Computers and Telecommunications [Member]
Computer Equipment [Member]
Software [Member]
Software And Software Development Costs [Member]
Furniture, Fixtures and Equipment [Member]
Furniture And Fixtures [Member]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Estimated useful lives of assets
Property Plant And Equipment Useful Life
Estimated useful lives of assets
Property Plant And Equipment Estimated Useful Lives
Amount of cumulative effect of the change in accounting principle or new accounting pronouncement on total assets.
Amount of cumulative effect of the change in accounting principle or new accounting pronouncement on liabilities.
Increase in total assets on the consolidated balance sheet due to adoption of ASU 2016-02
New Accounting Pronouncement Or Change In Accounting Principle Cumulative Effect Of Change On Assets
Increase in total liabilities on the consolidated balance sheet due to adoption of ASU 2016-02
New Accounting Pronouncement Or Change In Accounting Principle Cumulative Effect Of Change On Liabilities
Schedule Of Business Acquisitions By Acquisition [Table]
Schedule Of Business Acquisitions By Acquisition [Table]
Business Acquisition
Business Acquisition [Axis]
Business Acquisition, Acquiree
Business Acquisition Acquiree [Domain]
Spitfire Pharma, Inc.
Spitfire Pharma, Inc. [Member]
Spitfire Pharma Inc [Member]
Contingent Consideration by Type
Contingent Consideration By Type [Axis]
Contingent Consideration Type
Contingent Consideration Type [Domain]
Investigational New Drug Application milestone.
Investigational New Drug Application Milestone [Member]
Investigational New Drug Application Milestone [Member]
Investigational New Drug Application and Regulatory milestones.
Investigational New Drug Application and Regulatory Milestones [Member]
Investigational New Drug Application And Regulatory Milestones [Member]
Sales milestone.
Sales Milestones [Member]
Sales Milestone [Member]
Regulatory milestone.
Regulatory Milestones [Member]
Regulatory Milestone [Member]
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Agreement date
Business Acquisition Date Of Acquisition Agreement1
Number of consecutive trading days.
Percentage of upfront consideration release at period one.
Percentage of upfront consideration release at period two.
Percentage of upfront consideration release at period three.
Unregistered shares of common stock
Business Acquisition Equity Interests Issued Or Issuable Number Of Shares Issued
Up-front consideration
Payments To Acquire Businesses Gross
Number of consecutive trading days
Number Of Consecutive Trading Days
Upfront consideration release at 6 months
Percentage Of Upfront Consideration Release At Period One
Upfront consideration release at 12 months
Percentage Of Upfront Consideration Release At Period Two
Upfront consideration release at 18 months
Percentage Of Upfront Consideration Release At Period Three
Future contingent payments
Business Combination Contingent Consideration Liability
Business combination contingent consideration payment term.
Future contingent payment term
Business Combination Contingent Consideration Payment Term
Business acquisition term of license agreement.
License agreement term
Business Acquisition Term Of License Agreement
Stock price
Business Acquisition Share Price
Estimated discount for lack of marketability
Goodwill Written Off Related To Sale Of Business Unit
Percentage of upfront consideration release at period four.
Upfront consideration release at 3 months
Percentage Of Upfront Consideration Release At Period Four
In-process research and development expenses
Transaction cost recorded within research and development expense
Business Combination Acquisition Related Costs
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Restricted Stock [Member]
Restricted Stock [Member]
Other dilutive securities.
Other Dilutive Securities [Member]
Other Dilutive Securities [Member]
Option Indexed to Issuer's Equity
Option Indexed To Issuers Equity Equity [Axis]
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Domain]
Stock Options [Member]
Employee Stock Option [Member]
Common Stock Warrants [Member]
Warrant [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Property and equipment, at cost
Property Plant And Equipment Gross
Less accumulated depreciation and amortization
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Schedule of intangible assets.
Schedule Of Intangible Assets [Table]
Schedule Of Intangible Assets [Table]
Schedule Of Intangible Assets [Table]
Internally developed patents.
Internally Developed Patents [Member]
Internally Developed Patents [Member]
Acquired licenses.
Acquired Licenses [Member]
Acquired Licenses [Member]
Indefinite-lived Intangible Assets
Indefinite Lived Intangible Assets By Major Class [Axis]
Indefinite-lived Intangible Assets, Major Class Name
Indefinite Lived Intangible Assets Major Class Name [Domain]
Schedule Of Intangible Assets [Line Items]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives
Finite Lived Intangible Asset Useful Life
Intangible assets subject to amortization, Gross Carrying Value
Finite Lived Intangible Assets Gross
Intangible assets subject to amortization, Accumulated Amortization
Finite Lived Intangible Assets Accumulated Amortization
Intangible assets subject to amortization, Net Book Value
Finite Lived Intangible Assets Net
Total intangible assets, Gross Carrying Value
Intangible Assets Gross Excluding Goodwill
Total intangible assets, Impairment
Total intangible assets, Net Book Value
Indefinite Lived Intangible Assets Excluding Goodwill
Intangible Assets, Impairment
Impairment Of Intangible Assets Excluding Goodwill
Total intangible assets, Net Book Value
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
Oncosyn cancer immunotherapy.
Oncosyn Cancer Immunotherapy [Member]
Oncosyn Cancer Immunotherapy [Member]
HepTcell and SparVax-L.
HepTcell and SparVax-L [Member]
Hep Tcell And Spar Vax L [Member]
HepTcell.
HepTcell [Member]
Hep Tcell [Member]
SparVax-L.
SparVax-L [Member]
Spar Vax L [Member]
Amortization expense of intangible assets
Amortization Of Intangible Assets
2020
Finite Lived Intangible Assets Amortization Expense Next Twelve Months
2021
Finite Lived Intangible Assets Amortization Expense Year Two
2022
Finite Lived Intangible Assets Amortization Expense Year Three
2023
Finite Lived Intangible Assets Amortization Expense Year Four
2024
Finite Lived Intangible Assets Amortization Expense Year Five
2025 and thereafter
Finite Lived Intangible Assets Amortization Expense After Year Five
Number of assets.
Number of assets
Number Of Assets
Intangible assets, amount
Percent of fair value of reporting unit excess of carrying value
Reporting Unit Percentage Of Fair Value In Excess Of Carrying Amount
Fair value of intangible assets
Indefinite Lived Intangible Assets Excluding Goodwill Fair Value Disclosure
Carrying value of assets
Impairment charge
Schedule Of Indefinite Lived Intangible Assets [Table]
Schedule Of Indefinite Lived Intangible Assets [Table]
Indefinite Lived Intangible Assets By Major Class [Line Items]
Indefinite Lived Intangible Assets By Major Class [Line Items]
IPR&D Balance, beginning of period
IPR&D, Additions from the Mergers
Indefinitelived Intangible Assets Acquired
IPR&D, Foreign currency translation adjustments
Indefinite Lived Intangible Assets Foreign Currency Translation Gain Loss
IPR&D, Impairment charges
IPR&D Balance, end of period
Goodwill Balance, beginning of period
Goodwill, Additions from the mergers
Goodwill Acquired During Period
Goodwill, Foreign currency translation adjustments
Goodwill Foreign Currency Translation Gain Loss
Goodwill, Impairment charges
Goodwill Balance, end of period
Accrued research and development.
Accrued Liabilities And Other Liabilities [Abstract]
Accrued professional services
Accrued Professional Fees Current
Accrued payroll and employee benefits
Employee Related Liabilities Current
Accrued interest
Interest Payable Current
Lease obligation, current portion
Operating Lease Liability Current
Deferred rent, current portion
Deferred Rent Credit Current
Accrued research and development
Accrued Research And Development
Deferred revenue
Deferred Revenue Current
Total accrued expenses
Accrued Liabilities Current
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
University of Alabama at Birmingham Research Foundation.
University of Alabama at Birmingham Research Foundation [Member]
University Of Alabama At Birmingham Research Foundation [Member]
Janssen Vaccines and Prevention BV.
Janssen Vaccines and Prevention BV [Member]
Janssen Vaccines And Prevention Bv [Member]
Auburn university.
Auburn University [Member]
Auburn University [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Annual license fee
Payments For Fees
Type of Cost, Good or Service [Extensible List]
Type Of Cost Good Or Service Extensible List
License fee costs
Cost Of Goods And Services Sold
License agreement expiration period.
License agreement expiration period from the date of first commercial sale of relevant product
License Agreement Expiration Period
License Agreement Expiration Date
Upfront fees.
License fee costs
Cost Of Goods And Services Sold Depreciation
Patent expiration date
License Agreement Expiration Date
Upfront fee
Upfront Fees
Debt Instrument [Table]
Debt Instrument [Table]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
BPI France notes.
BPI France Notes [Member]
B P I France Notes [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Total notes payable
Economic conditional incentive grants.
BPI France notes, long-term portion
Long Term Notes Payable
Lease obligation, long-portion (see Note 15)
Operating Lease Liability Noncurrent
Deferred rent, long-term portion
Deferred Rent Credit Noncurrent
Common stock warrant liability (see Note 12)
Derivative Liabilities Noncurrent
Economic conditional grants
Economic Conditional Incentive Grants
Other
Other Liabilities Noncurrent
Total other long-term liabilities
Long Term Debt Noncurrent
Number of non-interest bearing research and development funding arrangements.
Percentage of fund to be withdrawn upon signing of arrangements.
Additional percentage of fund to be withdrawn, contingent upon financial audit and technical progress report.
Research and development funding arrangements extended period.
Paid in excess of allowable funding amount.
Grant [Member]
Grant [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Research funding first arrangement.
Research Funding First Arrangement [Member]
Research Funding First Arrangement [Member]
Research funding second arrangement.
Research Funding Second Arrangement [Member]
Research Funding Second Arrangement [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Montgomery county.
Montgomery County [Member]
Montgomery County [Member]
State of Maryland [Member]
MARYLAND
Montgomery County and State of Maryland.
Montgomery County and State of Maryland [Member]
Montgomery County And State Of Maryland [Member]
Stock Conversion Description
Conversion Of Stock By Unique Description [Axis]
Conversion of Stock, Name
Conversion Of Stock Name [Domain]
First warrants exchange.
First Exchange Warrants [Member]
First Warrants Exchange [Member]
Long-term Debt, Type
Longterm Debt Type [Axis]
Long-term Debt, Type
Longterm Debt Type [Domain]
Convertible Debt [Member]
Convertible Debt [Member]
Number of non-interest bearing research and development funding arrangements
Number Of Non Interest Bearing Research And Development Funding Arrangements
Debt instrument, face amount
Debt Instrument Face Amount
Percentage of fund to be withdrawn upon signing of arrangements
Percentage Of Fund To Be Withdrawn Upon Signing Of Arrangements
Additional percentage of fund to be withdrawn, contingent upon financial audit and technical progress report
Additional Percentage Of Fund To Be Withdrawn Contingent Upon Financial Audit And Technical Progress Report
Research and development funding arrangements extended period
Research And Development Funding Arrangements Extended Period
Total long-term debt
Long Term Debt
Long-term debt converted amount
Debt Conversion Converted Instrument Amount1
Paid in excess of allowable funding amount
Paid In Excess Of Allowable Funding Amount
Repayments of notes payable
Number of economic conditional incentive grants.
Economical condition incentive grant expiration date.
Economic conditional incentive grant term.
Accrued interest rate on grant.
Economic conditional incentive grants
Number of economic conditional incentive grants
Number Of Economic Conditional Incentive Grants
Expiration date of economic conditional incentive grant
Economic Conditional Incentive Grant Expiration Date
Economic incentive grant term
Economic Conditional Incentive Grant Term
Interest expense
Accrued interest rate on grant
Accrued Interest Rate On Grant
Weighted average prices of common stock.
Common Stock Weighted Average Price Per Share
Convertible notes principal balance
Convertible Debt
Shares of common stock called by warrants
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Convertible debt, interest rate in event of default
Debt Instrument Interest Rate Increase Decrease
Conversion price per share
Debt Instrument Convertible Conversion Price1
Weighted average prices of common stock
Weighted Average Prices Of Common Stock
Weighted average price per share of common stock
Common Stock Weighted Average Price Per Share
Number of trading days
Debt Instrument Convertible Threshold Consecutive Trading Days1
Additional interest earned.
Convertible note unamortized discount
Debt Instrument Unamortized Discount
Debt issuance costs
Deferred Finance Costs Net
Interest expense
Interest Expense Debt
Additional interest earned
Additional Interest Earned
Temporary Equity Disclosure [Abstract]
Temporary Equity By Class Of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Second warrants exchange.
Second Warrants Exchange [Member]
Second Warrants Exchange [Member]
Series B Preferred Stock [Member]
Series B Preferred Stock [Member]
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Convertible preferred shares, shares issued
Temporary Equity Shares Issued
Convertible preferred shares, par value
Temporary Equity Par Or Stated Value Per Share
Stock issued for exchange of warrants, shares
Stock issued for exchange of warrants
Stock And Warrants Issued During Period Value Preferred Stock And Warrants
Issuance costs incurred
Payments Of Stock Issuance Costs
Redeemable preferred stock redemption date
Preferred Stock Redemption Date
Percentage of common stock in reserve for issue on conversion
Debt Instrument Convertible Threshold Percentage Of Stock Price Trigger
Beneficial conversion feature
Debt Instrument Convertible Beneficial Conversion Feature
Fair Value Assets And Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Abstract]
Balance, beginning of period
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value
Changes in fair value
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Gain Loss Included In Earnings
Balance, end of period
Deemed dividend.
Deemed capital contribution.
Cash payment for outstanding preferred shares.
Conversion of Series B redeemable convertible preferred stock into common stock, shares
Conversion of redeemable preferred stock into common stock, shares
Face value of preferred stock
Preferred Stock Value
Face value of preferred stock, shares
Preferred Stock Shares Issued
Deemed dividend
Deemed Dividend
Number of shares issued
Sale Of Stock Number Of Shares Issued In Transaction
Proceeds from issuance of warrants
Payment For Outstanding Preferred Shares
Deemed contribution
Deemed Capital Contribution
Redeemable convertible preferred shares outstanding
Preferred Stock Shares Outstanding
Changes In Equity And Comprehensive Income Line Items [Line Items]
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
First registered direct offering member.
First Registered Direct Offering [Member]
First Registered Direct Offering [Member]
UnitOfferingMember.
Unit Offering [Member]
Unit Offering [Member]
Common units.
Common Units
Common Units [Member]
Pre-funded units.
Common Units [Member]
Prefunded Units [Member]
Second registered direct offering member.
Second Registered Direct Offering [Member]
Second Registered Direct Offering [Member]
Third registered direct offering.
Third Registered Direct Offering [Member]
Third Registered Direct Offering [Member]
Changes In Equity And Comprehensive Income Line Items [Line Items]
Changes In Equity And Comprehensive Income Line Items [Line Items]
Shares of common stock issued
Purchase price per share
Shares Issued Price Per Share
Net proceeds from offering
Placement agent fees and offering expenses
Expense Related To Distribution Or Servicing And Underwriting Fees
Class of warrant or right expiration period.
Class of warrant or right exercise price of warrants or rights 2.
Common units outstanding
Common Unit Outstanding
Public offering price per share
Sale Of Stock Price Per Share
Sale of transaction date
Sale Of Stock Transaction Date
Per share exercise price
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrant expiration period
Class Of Warrant Or Right Expiration Period
Per share exercise price
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights2
Common units issued
Common Unit Issued
Class of warrant or rights issuance date.
Classes or warrant right expiration date.
Class Of Warrant Or Right [Table]
Class Of Warrant Or Right [Table]
Class of Warrant or Right
Class Of Warrant Or Right [Axis]
Class of Warrant or Right
Class Of Warrant Or Right [Domain]
Replacement warrants.
Replacement Warrants [Member]
Replacement Warrants [Member]
Warrants Issued with Redeemable Preferred.
Warrants Issued with Redeemable Preferred [Member]
Warrants Issued With Redeemable Preferred [Member]
Warrants issued with common units in unit offering.
Warrants Issued with Common Units in Unit Offering [Member]
Warrants Issued With Common Units In Unit Offering [Member]
Underwriter warrant issued with public offering.
Underwriter Warrant Issued with Public Offering [Member]
Underwriter Warrant Issued With Public Offering [Member]
Issued with common units in the second registered direct offering.
Issued With Common Units in the Second Registered Direct Offering [Member]
Issued With Common Units In Second Registered Direct Offering [Member]
Issued with common units in registered direct offering.
Issued with Common Units in Registered Direct Offering [Member]
Issued With Common Units In Registered Direct Offering [Member]
Issued with common units in third registered direct offering.
Issued With Common Units in the Third Registered Direct Offering [Member]
Issued With Common Units In Third Registered Direct Offering [Member]
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Number of Common Stock Warrants
Class Of Warrant Or Right Outstanding
Per Share Exercise Price
Issuance Date
Class Of Warrant Or Rights Issuance Date
Expiration Date
Classes Or Warrant Right Expiration Date
Replacement warrants issued in connection with mergers.
Third warrants exchange.
Third Warrants Exchange [Member]
Third Warrants Exchange [Member]
Replacement warrants issued in connection with the Mergers
Replacement Warrants Issued In Connection With Mergers
Conversion of warrants into common stock and cash.
Issuances
Debt Conversion Converted Instrument Warrants Or Options Issued1
Conversion of warrants into common stock and cash
Conversion Of Warrants Into Common Stock And Cash
Warrants outstanding
Issuance of common stock for the exchange of warrants
Stock price per share
Cash proceeds from common stock
Gain loss on exchange of warrants.
Warrants transaction cost.
Proceeds from exchange of warrants
Proceeds From Warrant Exercises
Converted value in excess of principal
Debt Instrument Convertible If Converted Value In Excess Of Principal
Gain on exchange of warrants
Gain Loss On Exchange Of Warrants
Transaction costs
Warrants Transaction Cost
Face value of preferred stock
Exchange consideration discounted percentage
Debt Instrument Convertible Conversion Ratio1
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Expected Term (Years) [Member]
Measurement Input Expected Term [Member]
Risk-free Interest Rate [Member]
Measurement Input Risk Free Interest Rate [Member]
Dividend Yield [Member]
Measurement Input Expected Dividend Rate [Member]
Expected Volatility [Member]
Measurement Input Price Volatility [Member]
Measurement input
Debt Instrument Measurement Input
Common stock additional shares issued.
Proceeds from issuance of warrants
Proceeds From Issuance Of Warrants
Additional number of shares issued
Common Stock Additional Shares Issued
Loss on exchange of warrants.
Transaction costs allocated to warrants.
Change in fair value of warrant liability, including gain (loss) on exchange.
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
Changes in fair value of warrants
Loss on warrants exchanged
Loss On Exchange Of Warrants
Transaction costs
Transaction Costs Allocated To Warrants
Change in fair value of warrant liability, including gain (loss) on exchange
Change In Fair Value Of Warrant Liability Including Gain Loss On Exchange
Number of warrants exercised exchanged repurchased for conversion of securities.
Warrants outstanding, January 1
Exercises, conversions, exchanges and repurchases
Number Of Warrants Exercised Exchanged Repurchased For Conversion Of Securities
Warrants outstanding, December 31
Derivative liabilities recognized as result of settlement agreement.
Derivative Instruments And Hedging Activities Disclosures [Table]
Derivative Instruments And Hedging Activities Disclosures [Table]
Derivative Instruments And Hedging Activities Disclosures [Line Items]
Derivative Instruments And Hedging Activities Disclosures [Line Items]
Balance, January 1, 2018
Derivative Liabilities
Warrants settled upon exchange
Derivative Liabilities Recognized As Result Of Settlement Agreement
Warrant repurchases
Changes in fair value
Unrealized Gain Loss On Securities
Balance, December 31, 2018
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Risk-free Interest Rate [Member]
Expected Dividend Yield [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items]
Fair value of warrants, measurement input
Warrants And Rights Outstanding Measurement Input
Fair value of warrants, measurement input, expected term (years)
Warrants And Rights Outstanding Term
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand and one employee stock option plan.
2001 Employee Stock Option Plan [Member]
Two Thousand And One Employee Stock Option Plan [Member]
2007 Long-Term Incentive Compensation Plan.
2007 Long Term Incentive Plan [Member]
Stock Incentive Plan Twenty Zero Seven [Member]
2017 Omnibus Incentive Plan.
2017 Omnibus Incentive Plan [Member]
Two Thousand Seventeen Omnibus Incentive Plan [Member]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Director [Member]
Director [Member]
Two thousand and eighteen inducement grant plan.
2018 Inducement Grant Plan [Member]
Two Thousand And Eighteen Inducement Grant Plan [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Award Date
Award Date [Axis]
Award Date
Award Date [Domain]
October 2016.
October 2016 [Member]
October Two Thousand Sixteen [Member]
Scenario
Statement Scenario [Axis]
Scenario
Scenario Unspecified [Domain]
Forecast [Member]
Scenario Forecast [Member]
November thirty two thousand eighteen.
November 30, 2018 [Member]
November Thirty Two Thousand Eighteen [Member]
Vesting
Vesting [Axis]
Vesting
Vesting [Domain]
One Year Anniversary [Member]
Share Based Compensation Award Tranche One [Member]
36 Substantially Equal Monthly Installments
Share Based Compensation Award Tranche Two [Member]
Executive Officer [Member]
Executive Officer [Member]
Two thousand and nineteen employee stock purchase plan.
2019 Employee Stock Purchase Plan [Member]
Two Thousand And Nineteen Employee Stock Purchase Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Stock Options, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Percentage of additional shares from common stock available for stock-based compensation.
Common stock reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Shares reserved for future issuance, description
Share Based Compensation Arrangement By Share Based Payment Award Options Other Increases Decreases In Period Description
Percentage of additional shares from common stock available for stock-based compensation
Percentage Of Additional Shares From Common Stock Available For Stock Based Compensation
Stock granted, shares
Stock Issued During Period Shares Share Based Compensation Gross
Stock granted value
Stock Granted During Period Value Sharebased Compensation Gross
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract]
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Volatility Rate
Expected term (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Number of Stock Options, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Number of Stock Options, Exercised
Number of Stock Options, Forfeited or expired
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
Number of Stock Options, Outstanding
Number of Stock Options, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Number of Stock Options, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Weighted-average Exercise Price, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted-average Exercise Price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Forfeited or expired
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Outstanding
Weighted-average Exercise Price, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted-average Exercise Price, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Weighted-average Remaining Contractual Term, Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted-average Remaining Contractual Term, Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Weighted-average Remaining Contractual Term, Expected to vest
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Weighted-average Intrinsic Value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Weighted-average Intrinsic Value, Exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Weighted-average Intrinsic Value, Outstanding
Weighted-average Intrinsic Value, Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Weighted-average Intrinsic Value, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Weighted-average grant date fair value of stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Unrecognized compensation cost, stock options
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Unrecognized stock-based compensation expense, period for recognition
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Share-based compensation arrangement by share based payment award equity instruments other than options vested and expected to vest outstanding number.
Restricted stock authorized and granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Restricted stock authorized and granted, value
Stock Issued During Period Value Restricted Stock Award Gross
Weighted average grant date fair value of restricted stock award
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Restricted stock vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Fair value of restricted shares that vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Remaining shares to be vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested And Expected To Vest Outstanding Number
Share-based compensation arrangement by share-based payment award, award vesting rights, percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Share based compensation arrangement by share based payment award shares vesting date.
Share-based compensation arrangement by share-based payment award, shares vesting date
Share Based Compensation Arrangement By Share Based Payment Award Shares Vesting Date
Number of restricted shares vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Unvested Shares, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Vested Shares
Unvested Shares, Ending balance
Weighted-average Grant Date Fair Value Unvested, beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value Unvested, Ending balance
Unrecognized compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Percent of payroll deductions
Share Based Compensation Arrangement By Share Based Payment Award Maximum Employee Subscription Rate
Percentage of discount from fair market value of common stock on first or last trading day of offering period
Share Based Compensation Arrangement By Share Based Payment Award Discount From Market Price Offering Date
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock based compensation expense
Allocated Share Based Compensation Expense
U.S. operations
Income Loss From Continuing Operations Before Income Taxes Domestic
Non-U.S. operations
Income Loss From Continuing Operations Before Income Taxes Foreign
Net loss before income tax benefit
U.S. federal
Federal Income Tax Expense Benefit Continuing Operations [Abstract]
Current
Current Federal Tax Expense Benefit
Deferred
Deferred Federal Income Tax Expense Benefit
US state and local
State And Local Income Tax Expense Benefit Continuing Operations [Abstract]
Current
Current State And Local Tax Expense Benefit
Deferred
Deferred State And Local Income Tax Expense Benefit
Income tax benefit
Effective income tax rate reconciliation, share-based compensation cost, percent.
Effective income tax rate reconciliation acquisition costs.
Effective income tax rate reconciliation, nondeductible expense, goodwill impairment losses rate.
Effective income tax rate reconciliation nondeductible expense acquired in process research and development impairment.
Effective income tax rate reconciliation loss on warrant exchange and warrant fair market value changes.
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Effective Income Tax Rate Continuing Operations Tax Rate Reconciliation [Abstract]
Corporate federal income tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Foreign income tax rate differential
Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential
Stock compensation
Effective Income Tax Rate Reconciliation Sharebased Compensation Cost Percent
Research and development tax credit
Effective Income Tax Rate Reconciliation Tax Credits Research
Acquisition costs
Effective Income Tax Rate Reconciliation Acquisition Costs
Goodwill impairment
Effective Income Tax Rate Reconciliation Nondeductible Expense Goodwill Impairment Losses Rate
Acquired in process research and development impairment
Effective Income Tax Rate Reconciliation Nondeductible Expense Acquired In Process Research And Development Impairment
Loss on warrant exchange and warrant FMV changes
Effective Income Tax Rate Reconciliation Loss On Warrant Exchange And Warrant Fair Market Value Changes
Permanent differences and other
Effective Income Tax Rate Reconciliation Other Adjustments
Change in valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Effective tax rate
Effective Income Tax Rate Continuing Operations
Deferred tax assets amortization.
Deferred tax assets lease liability.
Deferred tax liabilities right of use asset.
Deferred tax liabilities depreciation.
Deferred tax liabilities, accrued compensation IRC Section 481A.
The amount of deferred tax assets, net of liabilities, before applying the valuation allowance.
Components Of Deferred Tax Assets And Liabilities [Abstract]
Deferred tax assets:
Deferred Tax Assets Net [Abstract]
Domestic NOLs
Deferred Tax Assets Operating Loss Carryforwards Domestic
Foreign NOLs
Deferred Tax Assets Operating Loss Carryforwards Foreign
Accrued expenses
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
Amortization
Deferred Tax Assets Amortization
Deferred revenue
Deferred Tax Assets Deferred Income
Stock compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Deferred rent
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Deferred Rent
Lease Liability
Deferred Tax Assets Lease Liability
Research and development carryforward
Deferred Tax Assets In Process Research And Development
Total deferred tax assets
Deferred Tax Assets Gross
Deferred tax liabilities:
Deferred Tax Liabilities [Abstract]
IPR&D assets
Deferred Tax Liabilities Deferred Expense Capitalized Research And Development Costs
Right of Use Asset
Deferred Tax Liabilities Right Of Use Asset
Depreciation
Deferred Tax Liabilities Depreciation
IRC §481(a) adjustment
Deferred Tax Liabilities Accrued Compensation Irc Section481a
Total deferred tax liabilities
Deferred Income Tax Liabilities
Deferred tax assets, net
Deferred Tax Assets Net Before Valuation Allowance
Valuation allowance
Deferred Tax Assets Valuation Allowance
Total deferred tax liabilities net
Deferred Income Tax Liabilities Net
Operating loss carryforwards, not subject to expiration.
Operating loss carryforwards, subject to expiration.
Operating loss carry forwards expiration period.
Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.
This table lists the income taxes. The line items identify information about the income taxes.
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
U.S. Federal [Member]
Domestic Country [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Net operating loss carryforwards
Operating Loss Carryforwards
Operating Loss carryforwards, subject to expiration
Operating Loss Carryforwards Subject To Expiration
Operating loss carry forwards expiration period
Operating Loss Carry Forwards Expiration Period
Net operating loss carryforwards, expiration date
Operating Loss Carryforwards Expiration Date
Operating loss carryforwards not subject to expiration
Operating Loss Carryforwards Not Subject To Expiration
Increase In Ownership Percentage
Testing Period
Ownership percentage
Increase In Ownership Percentage
Testing period
Testing Period
Non-cancellable lease maturity period.
Non-cancellable lease maturity period
Non Cancellable Lease Maturity Period
Operating lease rent expense
Lease And Rental Expense
Amortization of lease incentives benefit.
Amortization of lease incentive obligation
Amortization Of Lease Incentives Benefit
Cash paid for operating lease liabilities
Operating Lease Payments
Operating lease obligations
Operating Lease Liability
Weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate
Operating Lease Weighted Average Discount Rate Percent
2020
Lessee Operating Lease Liability Payments Due Next Twelve Months
2021
Lessee Operating Lease Liability Payments Due Year Two
2022
Lessee Operating Lease Liability Payments Due Year Three
2023
Lessee Operating Lease Liability Payments Due Year Four
2024
Lessee Operating Lease Liability Payments Due Year Five
2025 and thereafter
Lessee Operating Lease Liability Payments Due After Year Five
Total lease payments
Lessee Operating Lease Liability Payments Due
Less imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Total
Commitments and contingencies.
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Measurements, Recurring [Member]
Fair Value Measurements Recurring [Member]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents
Investments Fair Value Disclosure
Contingent consideration
Warrant liability
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
United States Treasury Securities [Member]
U S Treasury Securities [Member]
Corporate Debt Securities [Member]
Corporate Debt Securities [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Unrealized Gain
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Market Value
Available For Sale Securities Debt Securities
Measurement input cost of capital.
Cost of Capital [Member]
Measurement Input Cost Of Capital [Member]
Assumptions used to estimate fair value of contingent payments
Business Combination Contingent Consideration Liability Measurement Input
Defined Contribution Pension And Other Postretirement Plans Disclosure [Abstract]
Discretionary plan contributions
Defined Contribution Plan Employer Discretionary Contribution Amount