Altimmune Receives Award from U.S. Department of Defense to Fund Phase 1/2 Clinical Trial of T-COVID™ in Outpatients with Early COVID-19
As previously announced, patient enrollment in the T-COVID Phase 1/2 trial is expected to commence in the coming weeks, with data readout expected in the fourth quarter of 2020. If the Phase 1/2 clinical trial is successful, the Company plans to initiate a Phase 2/3 trial of T-COVID early next year and commence discussions regarding a potential Emergency Use Authorization.
“T-COVID represents one of the few investigational programs that targets outpatients with early COVID-19, with the goal of protecting them from progressing to severe disease and the need for hospitalization,” said
The T-COVID therapeutic program complements the Company’s novel single-dose COVID-19 vaccine candidate, AdCOVID, that utilizes the Company’s proprietary intranasal vaccine technology and has the potential to prevent infection by activating multiple arms of the immune system. On
T-COVID is based on the same replication-deficient adenovirus 5 (RD-Ad5) vector technology supporting Altimmune’s intranasal vaccine candidates, which include AdCOVID for COVID-19, NasoShield for anthrax and NasoVAX for influenza, but it works through the mechanism of immune modulation. In preclinical animal studies T-COVID modulated the innate immune response to decrease inflammation and significantly lower concentrations of IL-6 and other inflammatory cytokines in response to infection with respiratory viruses. Excessive production of inflammatory cytokines like IL-6 has been associated with the lung pathology and death in COVID-19.
Altimmune is a clinical stage biopharmaceutical company focused on developing treatments for liver disease, immune modulating therapies and intranasal vaccines. Our diverse pipeline includes next generation peptide therapeutics for NASH (ALT-801) and chronic hepatitis B (HepTcell™), an intranasal immune modulating treatment for COVID-19 (T-COVID™) and intranasal vaccines (AdCOVID™, NasoShield™ and NasoVAX™). For more information on Altimmune, please visit www.altimmune.com.
Any statements made in this press release relating to future financial or business performance, conditions, plans, prospects, trends, or strategies and other financial and business matters, including without limitation, the timing of key milestones for our clinical assets, the development of our T-COVID product candidate, initiation of a Phase 1/2 clinical trial for T-COVID in
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Source: Altimmune, Inc.